From the AgileTesting MailingList:
There's an agile team at Lockheed Martin flight software development: http://www.adtmag.com/article.asp?id=10093. It's Atlas V, not the shuttle, but they say: "If a rocket, for whatever reason, should come apart in the air... you can bet that our software will still be flying the biggest piece." -- ChrisMcMahon?